Claypool told MusicRadar
why he discussed such a dark subject matter with humor on this song: "There's a lot of crazy s--t in my life right now: My mom is fading away from us; she's not going to be around much longer. My little nephew was diagnosed with leukaemia at only two months old. I have friends battling cancer. When I wrote that song, I was just like, 'Holy f---ing hell…' Whatever metaphor you want to use: Into everyone's life a little rain must fall. Well, there you go – Tragedy's A-Comin'.
The funny thing is, the music to that song is very uplifting. I love the contrast of it. From Tommy The Cat
to Wynona's Big Brown Beaver, there's a lot of tragic figures in my music and Primus' music. It's just the way I exercise my demons, through these kinds of people."