This song was inspired by the overwhelming public ridicule arising from Fantasia's relationship with a married man that drove her to attempt suicide in 2010. The singer penned the tune with composer Andrea Martin. "We sat down and put our feelings into the song," Fantasia told The Drop.FM
. "It was the last song we recorded, so it was so special. It was special to her. We both have been through some things."
Fantasia added that she turned her negative experiences into a positive outlook on life. "I've lost a lot, but I'm winning now. When I say winning, I am not talking about money, cars or material things. I am finally at peace," she said. "'Lose to Win' had to be my first single because it is my testimony. I want to acknowledge the small things in life that we forget. I am not just talking about relationships. We lose jobs, homes, look at the people in Boston [the interview was done just after the Boston Marathon's terrorist bombings]."