Lyrically, the song finds Urie telling the story of being compulsively in love with an elusive woman. It references Janet Jackson's classic hit "Nasty
." Urie told MTV News it's a true tale from his personal life. "'Miss Jackson' is about something that actually happened to me when I was younger. I hadn't really talked about it, and I felt that if I didn't, I would keep thinking about it, it would drive me crazy," he explained. "When I was younger, I would mess around; I'd sleep with one girl one night, sleep with her friend the next night, and not care about how they felt, or how I made them feel. And then it happened to me and I realized 'Wow, that's what that feels like? I feel really sh---y.'"
"I knew I had to change, because I didn't want to feel that way again, or make other people feel that way," Urie continued. "So I wrote the song. It's based off someone who is real, though I don't think they would know it. They might suspect it, and if they figure it out, I'd love to talk to them about it."