Many people think this is about suicide, but the song is actually about hope, to fight against the odds. Shinedown lead singer Brent Smith told Foundry Music
: "I think a lot of people kind of take a literal sense because of the lyrics - but the song is basically about the day that you wake up and you look at yourself in the mirror and you finally decide that you want to try to become comfortable in your own skin, and realize that you're gonna have to make yourself happy before you're going to make anyone else happy. And basically, the 45 isn't an actual literal term for a gun, I used it as a metaphor for the world, the 45 is actually the world and what it hands you every day of your life. When you get up, it's a gift to be alive to begin with. A lot of different people, when I've talked about it, they said, 'Do you really honestly mean that?' And I'm like, 'Well, yeah.' Because I've been in that situation where I didn't know if I wanted to continue going on and I didn't know how to necessarily make myself comfortable with who I was, trying to find a way of learning more about myself. And you come from a dark place sometimes, and that's really the reality of the song. It's about overcoming and about moving forward. And it's basically about understanding that it's not always going to be good, but you really have no one to blame for yourself if you don't move forward. That's where the whole, 'Nobody knows what I believe,' comes from because we're all individuals. So that's really where it comes from, it's about moving on, really."