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The '60s was a time for traveling and discovering your place in the world. Sometimes what you found was an empty existence that just keeps repeating itself day to day. Having to deal with everyday life when you were always waiting for some kind of revelation to expand your consciousness was often depressing. The Grateful Dead sang of acceptance of banality and the drive to continue their search for epiphany.
One verse in particular: "What in the world ever became of sweet Jane, she lost her sparkle. Well you know she isn't the same. Living on reds, vitamin C and cocaine? All a friend can say is ain't it a shame." seems to refer to the endless desperation that overtakes some people. They turn to drugs to provide meaning in their lives. This of course fails and spirals their lives into deeper depression. Drugs are for enhancing a good time spent with good friends. They cannot provide answers to the meaning of life. The previous verse speaks to commonplace usage and the consequences of accepting illegal activities as a normal part of your life. You often get "busted" by the police. (thanks, James - Rochester, NY)
Artis the Spoonman
Even before Soundgarden wrote a song about him, Artis was the most famous spoon player of all time. So why has he always been broke?