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The title is a play on the word "Hoodoo," which is a folk religion similar to Voodoo and also popular in the American South. Many Blues musicians mentioned Hoodoo in their songs and like Diddley, conjured up images of the skulls, snakes and graveyards.
Diddley was know for the distinctive guitar riff he used in this song, which became known as "The Bo Diddley Beat."
George Thorogood And The Destroyers recorded a popular cover on their 1978 album Move It On Over. In 1982, Diddley appeared in Thorogood's video for "Bad To The Bone." It was good timing, since MTV was new didn't have many videos.
British blues rockers Juicy Lucy had a #14 hit in the UK in 1970 with their version of this. (thanks, Edward Pearce - Ashford, Kent, England)
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