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This was written in just one sitting after the death of bass player Cliff Burton, who played in Metallica with Megadeth guitarist Dave Mustaine. The lyrics, however, are not directly about Burton, as the song is about remaining true to your friends no matter who they hang out with (there was a lot of tension between Mustaine and the members of Metallica). (thanks, Dave - Calgary, Canada)
"Missing You" was a spontaneous outpouring of emotion triggered by a phone call. John tells that story and explains what MTV meant to his career.