The song title refers to the Ancient Greek myth about the gifted musician, Orpheus. The stories about Orpheus are centered on his ability to charm all living things with his singing and his unsuccessful attempt to rescue his dead wife from the Underworld.
Frontman Win Butler became a father during the recording of Reflektor and his son was immediately drawn to this tune. He told The Sun: "We played that song to him a hundred thousand times in the womb. If he is crying now, we play him that song and it quiets him."