This slow blues number refers to the wife literally from hell and it concludes with a demonic cackle from Dylan. The singer-songwriter legend can also be heard laughing on "Bob Dylan's 115th Dream," a track on his 1965 album Bringing It All Back Home.
Chicago blues has always been a huge influence on Dylan, and on this song he borrows from Willie Dixon's "I Just Want to Make Love to You."
Dylan borrowed the line "I'm pretty sure she'll make me kill someone," from Geoffrey Chaucer's medieval masterpiece Canterbury Tales. The quote appears in a translation of the prologue to The Monk's Tale.
In an interview published on Dylan's website, he was asked if he really believed the line in this song: "Dreams never did work for me anyway." Dylan replied: "Well, yeah. Dreams can lead us up a blind alley. Everybody has dreams. We go to sleep and we dream. I've always thought of them as coming out of the subconscious. I guess you can interpret them. Dreams can tell us a lot about ourselves, if we can remember them. We can see what's coming around the corner sometimes without actually going to the corner."