This is the title track of Bush's sixth studio album. The song finds frontman Gavin Rossdale
singing of feeling "the walls closing in," as he nears his 49th birthday. "When you first began writing songs, you see the world as infinite, and your time as infinite, because that's the nature of being young," he explained to Rolling Stone
. "As you get older, you see it as chapters."
"The title 'Man on the Run' is meant as a universal take on a slice of my life and the people I come across," Rossdale added. "It just seems that the doors are closing and everyone is trying to figure out their way. It's the most universal title I've ever had. I always figure everyone is on the run."