Guitarist Mike Einziger came up with the song's guitar part before the rest of it followed. He told Rock Sound
magazine: "For me it sounds like a 1970's version of our song 'Drive
'; the working title of the song was 'Drive 1974.' It was a musical idea that I really felt strongly about, and I felt that it could turn into something great. We were all listening to a lot of Phil Collins when we decided to put that song together, and the drums on 'Isadore' were inspired by that."