Little Big Town's Phillip Sweet
said of the song: "It's not what you think it would sound like when you hear the word 'pain killer.' You think, 'Oh, this is going to be like a ballad or a heart wrenching country song,' but it's so not that. It's amazingly fun."
"Every time I hear it, it just puts me in the right mood. It puts me in the – it's basically a love song. It's about how much you love that other person in your life and they are your pain killer."