Lyrically, the song is centered around clips of an interview with Rickie Lee Jones, who talks dreamily of the fluffy clouds in the Texan skies of her childhood. The conversation comes from a CD that was distributed to record stores and media outlets to promote her 1989 album Flying Cowboys
. Jones later said in interviews that the odd nasal tonality of her voice was the result of a heavy cold. Also incorporated is a guitar figure from American minimalist composer Steve Reich's "Electric Counterpoint," as recorded by Pat Metheny, and a harmonica sample from Ennio Morricone's "The Man With The Harmonica" from the soundtrack of the 1968 spaghetti Western Once Upon a Time in the West
Speaking with The Guardian
, Youth explained how he came across the audio for the Rickie Lee Jones and Steve Reich samples. "A fan who worked in a record shop in Birmingham sent me a tape with a note saying it would be perfect for the Orb. On one side, Pat Metheny was playing Steve Reich's 'Electric Counterpoint.' On the other was an interview with Rickie Lee Jones. Someone asked her: 'So what were the skies like when you were young?' and she launched into a trippy monologue about stars and clouds. I sampled it and put it over a basic pulse. That was the start of 'Little Fluffy Clouds.'"