Released in the summer of 1994, "Regulate" was the breakout single for both American West Coast rapper Warren G and singer Nate Dogg. In an interview with DJ Skee, Warren recalled that Nate recorded his portion of the hit in a closet. "I had an apartment on Long Beach Boulevard and San Antonio, and I didn't have no furniture," he reminisced. "I had dog s--- all over the floor, and I had two bedrooms. In one of my bedrooms, all I had was studio equipment. I did the sample, plugged in my VCR into the MPC60, sampled [the music], and after I finished it, I called Nate, and said 'Nate, I got a record I think we should do, and go back-and-forth on it. I think it'd be dope.' He came over, he heard it, and was like, 'Damn!' So from there, we hooked up a mic in the closet, and I called my engineer, Greg. He came over and recorded it, and there it is."
The song sampled the 1984 Michael McDonald hit "I Keep Forgettin' (Every Time You're Near)." It also features a quote from jazz performer Bob James' 1981 track "Sign of the Times" and dialogue spoken from the 1988 film Young Guns.
The song appears on the soundtrack to the film Above The Rim and the music video also features scenes from the movie.
In the early 1990s Warren G and Nate Dogg were in a group called 213 with a certain Snoop Dogg, who was known as Snoop Doggy Dog at the time.
Warren G is the stepbrother of rapper and producer Dr. Dre. They share the same mother but have different fathers.
Nate Dogg died on March 15, 2011 in Long Beach, California of congestive heart failure, along with complications related to two previous strokes.