This was the first song to be promoted from Californian rockers Cake sixth studio album, Showroom of Compassion. "Sick Of You" was Cake's first new song in six years.
Frontman John McCrea explained the song's meaning to Spin magazine: "It's about how when you hate things, the circle of hate starts rather broadly. You hate the President or a big movie star, someone you'll probably never meet. Gradually though, the circle tightens and the objects of hate get closer and closer to the hater. Now it's your uncle or your mother, now it's your close friend, and finally it's you. Bummer."
Showroom of Compassion debuted atop the Billboard 200 with sales of 44,000, making it the lowest selling album to make it to #1 in the history of the chart. The album plummeted from the top position to #25 in its second week on the Billboard 200, the largest fall from the summit since Incubus' Light Grenades plunged from #1 to # 37 in its second week in December 2006. Cake only held onto the bittersweet record for a fortnight as two weeks after Showroom of Compassion reached #1, Amos Lee's Mission Bell debuted at the top of the Billboard 200 with sales of just 40,000.