Michele told Billboard magazine that she named her sophomore album after this Ne-Yo penned track as a result of having a realization about relationships. Michele was referring to the relationship with her former manager, Douglas "Biggs" Ellison, who Michele sued for embezzlement and harassment in 2008. She explained: "I heard the song that Ne-Yo had written titled 'Epiphany,' and the word just stood out to me. It stood out to me because I'd been through a lot in my last relationship, and the word 'epiphany' exemplified exactly what happened in the end when I realized I didn't have to put myself through it anymore."
The album debuted at #1 on the US Billboard charts. However the week-ending sale total of 83,000 copies was the lowest for a #1-entering album since tracking firm Nielsen Soundscan's started keeping records in 1991. A few months later, the Country duo Sugarland clocked up a new low when their Wal-Mart exclusive CD/DVD package Live on the Inside debuted at #1 with 76,000 sales.
"Kickstart My Heart" is about all the ways Motley Crue gets their blood flowing without drugs. It was inspired by their bass player Nikki Sixx, who claimed he had to be revived with a shot of adrenaline to the heart after an overdose.