This song features Kanye West. Christina Milian told MTV News how she came to hook up with the superstar artist and producer: "It kind of just happened. We happened to be in the same studio. I asked him to come in, and he heard it and got on it immediately. I'm glad I got to have him a part of my album." Milian added that working with West was a breeze, despite his reputation for being a perfectionist. Said the singer: "He's very creative. He can make three beats in one night and hum several different melodies on each record and then from there go back to the record and write the songs. When he came to my project that's kind of what happened. He happened to be in the studio working on his project. He heard it, he hummed out some melodies and lyrics, and the next day he put down his vocals. It's very easy breezy. I'm sure he wouldn't have gotten on it if he didn't like it."
Angus Young created the distinctive opening guitar part for "Thuderstruck" by playing with all the strings taped up, except the B. He learned the studio trick from his older brother George Young, who was the rhythm guitarist for The Easybeats.