Frontman Grant Nicholas told Kerrang! magazine June 21, 2008 about this song: "I was trying to put myself in the mind of a youth who might be living in a bleak kind of place and who has just been through a break-up. That's kind of what it's about. I had been reading a lot of stuff about youth and knife crime and I think that inspired me. There are a lot of personal things in there, too. I need lyrics to mean something to me, otherwise I can't sing them so well."
Two tears roll down Sinead O'Connor's face. toward the end of the video for "Nothing Compares 2 U." They were shed because she associated the song's lyrics of love and loss with her mother, who was killed in a car accident in 1985.