This features vocals by Vic Mensa. The collaboration came about after Flume linked up with the Chicago rapper in his hometown of Sydney. The Australian musician recalled to The Chicago Tribune:
"He was playing a festival, and I was a fan of what he was up to. I hit him up, and we go in the studio together, and he played some of his ideas he was working on and I played him some of my stuff. There was a particular idea of mine that I was working on that he was really excited about, and that became 'Lose It.'"
The song originally had a different title. Flume explained: "I thought the weird sound at the start of the track sounded like electronic whale calls, so before Vic got on it, this track was called Electro Whale Symphony."