This is the opening track of American rock and jam band Gov't Mule's eighth studio album, By a Thread.
This track features the guitar playing of ZZ Top's Billy Gibbons. Guitarist Warren Haynes explained to Billboard magazine how the collaboration came about: "That was the last song we wrote and recorded for the CD, and when we listened back to it we thought, 'Wow, it's kinda got an old school, early-ZZ Top vibe about it.' We sent him the track and he loved it. I flew to L.A. and sat in a room with Billy, and we overdubbed our guitars at the same time because I wanted us to be staring each other in the face when we did it. He was so amazing and added so much to the track that it's hard to think of it without him now."
"Islands in the Stream" was originally written by The Bee Gees as an R&B song. It was originally written by the brothers for Marvin Gaye, however it was recorded instead as a duet by Kenny Rogers and Dolly Parton with the Gibb Brothers also contributing vocals.