This song is about the singer's younger sister Emily Newsom. More autobiographical than most of Joanna Newsom's compositions, it bemoans how life has taken the sisters on different paths, and how they aren't as close as they were as children.
Emily Newsom contributed backing vocals to the tune.
This was ranked #9 in Pitchfork Media's Top 100 Tracks of 2006.
When "Nothin' On You" reached #1 on the Hot 100, B.o.B became the first American act whose name is a palindrome to top the chart. The other two who did so prior to the Atlanta rapper were both Scandinavian groups - ABBA and A-Ha.