The lyrics center on Thomas coming to terms with how uncomfortable he felt as a rock star. He recalled the story behind the song in a Genius
"We were going into our third record. It came from the idea of still not feeling comfortable in my own skin, and the job sometimes even less so. I was always very comfortable in small groups, and I was always very comfortable on a stage. And then never comfortable in the group. You'd do things where you're out and amongst, and I was never really comfortable.
That led me to having really crazy panic attacks and having to figure out a way to get all of that under control. Once I started to get older, once I started to grow up, the fabrication that I'd made of how comfortable I was and how secure I was in myself started to go away. I was left with the reality I need to deal with how uncomfortable I am at all times, how unsure of myself I am, every word that comes out of my mouth, in every situation. 'Unwell' was the beginning of that for me."