Sebastian Bach isn't saying in this song that all his friends are dead in a physical sense but more in terms of the expression, "you're dead to me." He explained to Guitar World: "It can be somebody that's still physically alive, but you're no longer friends with. It can also play into the lifestyle that people lead, and in this business a lot of people die. So that has a lot to do with it too."
The song's music video features Duff McKagan from Guns N' Roses on guitar (he also played on the album) and Will Hunt from Evanescence, on drums.
Lily Allen wrote "Something's Not Right" for the soundtrack of the Peter Pan prequel, Pan. The song was inspired by the heartache that Allen experienced after suffering a miscarriage when she was six months pregnant with her first child by husband Sam Cooper in 2010.