"In My Blood" sees a much more vulnerable, raw side of Mendes. "I'm really proud of it," he told Billboard
. "I think, especially, comparing that to all of my other music – I love all of my other songs, but…it was all kind of more vague topics about a relationship, and this is my first time breaking into something that's more serious and more about me."
"The concept of this song is about how it feels [when] you're about to give up, and then you don't," Mendes continued. "That's the whole payoff in the chorus section…It's about something that I think everybody goes through and it's something that I think people don't talk about often, especially in music."