The second single from Human, this topped Billboard's Mainstream rock radio chart giving Three Days Grace its thirteenth #1 song on the survey. It broke the Canadian band's own record for the format of twelve chart-toppers.
Three Days Grace drummer Neil Sanderson said about the track: "Sonically, we wanted to create a 'machine-like' sound in parts of the song. We were inspired by the images from the opening scene of Tim Burton's Edward Scissorhands… relentless machines turning and churning, never ceasing to operate."
Neil Sanderson explained the track's meaning: "Lyrically the song is about how sometimes you feel like you are in an endless routine and cannot escape," he said. "You begin to feel numb to the world around you, as you yearn to just feel anything, any emotion."
When "Nothin' On You" reached #1 on the Hot 100, B.o.B became the first American act whose name is a palindrome to top the chart. The other two who did so prior to the Atlanta rapper were both Scandinavian groups - ABBA and A-Ha.