Vocalist Jeremy McKinnon explained the meaning of this song to Kerrang!: "This is about a friend, or somebody close to you, telling you something that makes you look at them different. You think, 'Maybe you're a different person than I thought you were?' That's the vibe of this: 'I'll never feel the same about you.'"
Mike Campbell from Tom Petty & the Heartbreakers played the slide guitar on "Sixth Avenue Heartache." There is a connection here - Wallflowers lead singer Jakob's dad, Bob Dylan, played with Tom Petty in The Traveling Wilburys.