Vocalist Andy Six told the story behind this song in an interview with Kerrang!: "Lyrically I had pretty much the whole song mapped out in my head for a long time. Some of the kids we hear from are really going through some stuff, they; they write to us on the internet and tell us about the difficult things they have to face in life. We want to give a positive message to our audience, though we don't always know how to help in that regard, but we promise that we will always try and if nothing else we can lend our music as a helping hand."
"It's the End of the World As We Know It (And I Feel Fine)" was inspired by a dream where Michael Stipe conjured up images of people with the initials L.B.: Lester Bangs, Leonid Breshnev, Lenny Bruce and Leonard Bernstein.