This song draws on Christopher's brother's experiences serving in Basra, Iraq. He told the Metro newspaper July 7, 2008: "I was thinking about why he was there and if it's the right thing to do. It's a song wondering why we're on the planet."
Bryn Christopher told The Sun September 4, 2008 about this song: "(Bryn's brother) Tyler had just been sent to Iraq. He was fighting for this country but really our country is fighting for America. I started thinking, 'Are we helping them out so that they can help us out if we ever get into trouble? Does my brother believe in the cause?' I never ask him questions because it's his job. I'm sure he'd just say: 'You don't have to worry about me. I'm more likely to get run over by a car or by a bus.' Anyway, what would be the point of training to be a fighter and never going to war? That whole situation led me to think, 'What am I here for? Why am I living on this earth? Why are we all here? What can I do as an individual for the good of people, animals, the atmosphere?' The song's saying that I can't answer these questions now - I'm only 22 - and maybe we'll never answer them."
This featured in the final episode ("Losing My Mind") of season 4 of Grey's Anatomy.
When "Nothin' On You" reached #1 on the Hot 100, B.o.B became the first American act whose name is a palindrome to top the chart. The other two who did so prior to the Atlanta rapper were both Scandinavian groups - ABBA and A-Ha.
In The Beatles "When I'm 64," Paul McCartney asks a woman if she'll still be there for him when he's 64. In 2006, he got his answer when shortly before his 64th birthday, he and Heather Mills separated.