Cancer Bats are one of the hardest working bands in the music industry, spending close to 300 days away from home in 2011. Frontman Liam Cormier told Terrorizer magazine that though this song is about his own struggles with the hardships that come with a career spent on the road, he hopes others will relate to the song's sentiments about being away from loved ones. He explained: "'Road Sick' is my one tour song that I still have on the album, but trying to change up. I mean as we've been on tour for six years, it's like now I'm not really trying to glamorize it, it's trying to look at the other side of it.
My big thing with this one too though was I didn't necessarily wanna write this specifically for myself. When I meet people at shows, and talk to people, a lot of people come up to me and tell me they appreciate all the songs like 'Lucifer's Rocking Chair' and the big one is guys who are in the army will tell me how they listen to 'Hail Destroyer' while they're in Afghanistan and traveling. So it's like my song for all of us, obviously the verses and stuff are specific about me but just the idea of being away from the ones you love, you're just trying to get through and work as hard as you can.
Even as I say in the chorus, it wasn't exactly what you planned but you're doing your best with what you've got. I meet guys who have one foot and they're with their wife and they're like "you know what, I never planned on going there and getting my foot blown off but man I listened to 'Hail Destroyer' every day while I was there" and I'm just like "holy s--t!". So that song was about tour but also about all those people that I know that can relate to tour songs just as much, if not more."