This song is a family affair, deriving its dreamlike sensibility from the ethereal vocals of Neil Finn's wife, Sharon Dawn Johnson. The song's coda benefits from the psychedelic guitar work of Liam Finn, Neil's son and long-time collaborator in the studio and onstage.
Finn told Spinner UK about his wife's contribution to this song: "She's done some aaaahs and oohs and various things in the past and I've always known she had a lovely tone in her voice, but it was Jim Scott's idea that the song Isolation might take a woman's voice in the second verse, that juxtaposition. And we tried it with her, and I thought it sounded beautiful."
Two tears roll down Sinead O'Connor's face. toward the end of the video for "Nothing Compares 2 U." They were shed because she associated the song's lyrics of love and loss with her mother, who was killed in a car accident in 1985.