Clark said regarding Love This Giant: "We started our collaboration around the fall of 2009 after being approached by [New York charity] Housing Works to write and perform a night of new music for charity. We decided to centre the music around a brass band and began sending ideas back and forth in every form: wordless melodies, melody-less songs. After a while we had enough of a body of work that David, not one to do anything by half, suggested we record it and put it out. I am very proud of what we created and excited for it to hit your ears."
Byrne added: "A lot of people, hearing a description of this project, assumed that it might be an artsy indulgence, but somehow it didn't turn out that way. It's a pop record - well, in my book anyway. I started to sense that we were ending up with a sound and approach I'd never heard before. There were elements that were reminiscent of things I'd heard, but a lot of it was completely new."