This noisy tune is the title track of Deerhunter's sixth studio album. The record was the American indie rock band's first to feature the new bassist, Josh McKay (who replaced Joshua Fauver), and new guitarist Frankie Broyles of band member Lockett Pundt's side project Lotus Plaza. The disc was recorded at Rare Book Room Studio in Brooklyn, with producer Nicolas Vernhes, who also helmed Deerhunter's 2008 Microcastle album and 2009 Rainwater Cassette Exchange EP.
Monomania is a behavioral disorder in which a person takes an unreasonable interest on one particular idea. It is a reference to lead singer Bradford Cox's obsessive traits.
The song was debuted on April 2, 2013 on Late Night With Jimmy Fallon.