Guitarist Dan Donegan discussed his solo on this track with Ultimate-Guitar.com
: "Some songs just depend on how I feel that day. For 'The Infection' I was so pumped up from the opening of the riff and just kind of that high-energy riff that by the time we got to that middle section because of the adrenalin rush and the excitement from the energy from the previous parts, I felt like riffing into that. I felt like going into maybe a longer [section.] It's probably the longest or one of the longer extended solos on this body of work."