This is the first single from Texas-based Rock band Flyleaf's second album, Memento Mori.
Lead singer Lacey Moseley explained the song in a letter written to fans: "It is written for people like me, who feel a restlessness to make the world better somehow, but are much to small to carry the weight of the world on their shoulders. Its to say, you have the right heart, but you weren't meant to carry it all. You are so strong, you are able to handle so much! But you can't handle everything all at once. Let go! God's big and He can handle it all better than you! Its okay to let go and not understand everything."
Flyleaf debuted this song in early 2007 when touring in support of their self-titled debut album. However the lyrics to the song changed after they decided to record it. Mosley explained: "The fans seem to know what's happening with us before we do and I'm not surprised to find out many have known the lyrics to 'Again' for a year now. :-) The first verse and chorus did change in the studio! It is a good thing, because the words say better what my heart meant."
Memento Mori takes its title from the Latin phrase, which translates as "Remember you shall die." The band said they hoped it would encourage people to make the most of every moment.
The song's music video was directed by Meiert Avis (Avril Lavigne, U2, Bruce Springsteen). Guitarist Sameer Bhattacharya told MTV News that the video's concept ties in with the album title. He explained: "The whole theme is that everything comes to an end. But there's always hope and a bigger picture too." The woodcuts in the video that are formed from light and energy were created by bassist Pat Seals, who also designed all the artwork for the album.