Songfacts®:

• Medicine At Midnight is the Foo Fighters' 10th album. Frontman Dave Grohl has likened the record's sound to David Bowie's "Let's Dance," and its title track in particular pays tribute to the 1983 hit. "It's a huge f--king rock song that I imagine opening every festival from here to Melbourne," he told NME.
• The Foo Fighters started recording for Medicine At Midnight in October 2019 at a house in Encino, Los Angeles. Originally scheduled for 2020, the album was delayed because of COVID. Though Grohl penned his lyrics before the coronavirus era, many of them apply to the traumas caused by the pandemic. This song is a case in point.
  
  Medicine at midnight calling, but it ain't no cure
  I may be sick, but you know I'm yours
  
  Grohl told UK newspaper The Sun he loved the song's lyric, "because medicine represents some sort of healing and midnight represents desperation. And people feel some sort of desperation and are in need of healing, whether that's a vaccine or a f---ing shot of whiskey before bed."
• Percussionist Omar Hakim appears on this song and several other Medicine At Midnight tracks. He played drums on Bowie's Let's Dance album.
• Foo Fighters achieved their fifth UK #1 album with Medicine At Midnight, following One By One (2002), Echoes, Silence, Patience & Grace (2007), Wasting Light (2011), and Concrete & Gold (2017). The record debuted at the top spot with 42,500 chart sales, outselling its six closest rivals combined.