This song has just one line repeated over and over: "My brother and my sister don't speak to me but I don't blame them." Blake explained the lyric to Q magazine: "Well, I'm an only child. You could psychologically pick that apart but it was an in-joke. I didn't resent being an only child, but I saw that other people had brothers and sisters and I always felt slightly sorry for myself that I didn't learn to socialize, (but) there's a contentment with your own company."
When "Nothin' On You" reached #1 on the Hot 100, B.o.B became the first American act whose name is a palindrome to top the chart. The other two who did so prior to the Atlanta rapper were both Scandinavian groups - ABBA and A-Ha.