The Australian singer-songwriter was adamant about "Ain't No Little Girl" being the first single from her 11th album, Dragonfly. "It's the first song in my life I truly feel 'wrote me' rather than me writing it," Kasey Chambers explained in her 2017 Songfacts interview. "I wrote it a few years back and never connected to it much because I honestly felt like I wasn't strong enough personally or vocally to really 'own it.'"

Chambers went on to express how vocal surgery changed her. "I grew into the song throughout a lot of personal growth and after vocal surgery having two nodules removed from my vocal chords, I found a new strength and power within myself as a singer and a woman," she said. "It became a theme to new life, and I feel is the most important song I've ever written. It is the glue that holds the whole album together, and my life!"

Chambers revealed to The Australian that the powerful track can be quite fragile as well. "It's not all strong, though," she said. "In the verses there are really vulnerable moments where I feel like I could cry, but it's always overpowered by strength in the chorus. And that's what it's about. That's me.'"