Tim Rice-Oxley started this song in the back of the band's touring bus on a boiling hot day in Boston in the summer of 2010. He explained: "It was right after the show, and I was first on the bus so I cracked open a cold beer and picked up the guitar, and this spilled out straight away. That's my idea of heaven. We were in Lincoln, Nebraska a couple of days later and everyone had gone off to get some rest in the hotel. The tour bus was parked up outside for the day so I thought I would go on there and be able record the piano and vocal for the demo without disturbing anyone. Anyway I was singing away merrily when I felt the bus pull away and before I knew it I was heading out of town - I ended up doing most of the demo outside a Walgreens in the back-end of nowhere. I'm not sure the bus driver ever realised I was on board."
Lyrically, the song considers the ease with which the idealistic youth can turn a bad situation around. "Forget the ghosts that make you old before your time," exhorts vocalist Tom Chaplin. "I like the idea of having to almost make a physical effort to get back on track sometimes," explained Rice-Oxley, "if you get really low or things just aren't going right. It's a very sympathetic song, and I think it a good articulation of the human sympathy that is a big part of what ties the album together."
"Kickstart My Heart" is about all the ways Motley Crue gets their blood flowing without drugs. It was inspired by their bass player Nikki Sixx, who claimed he had to be revived with a shot of adrenaline to the heart after an overdose.