Keb' Mo' wrote this pandemic-themed tune, featuring Old Crow Medicine Show, while he was staying with his family in California during the coronavirus lockdown. He watched several TV interviews of Dr. Anthony Fauci discussing the virus and it sparked an idea for a song about coming down with Covid-19 and waiting on "The Medicine Man" for a vaccine.
In a 2022 Songfacts interview with Mo'
, he said the song idea came to him in the middle of the night, and he hammered it out the next day. "I got up in the morning and did a demo and sent it to Ketch [Secor], the leader of The Old Crow Medicine Show, who I'd been talking to," he explained. "Over the years, we'd been talking about the possibility of doing a collaboration, and when I sent it to him, the light went on and he said, 'That's it! Let's do it.'"