This is one of several tracks on The Paradigm Shift that reflect frontman Jonathan Davis' struggles to detox from antidepressant medication. He told Rolling Stone: "Writing the record was really weird. They started writing, I think, in August (2012), and I didn't get into the studio until March, because I was going through all kinds of crazy s--t. My boy got diabetes and I had come off medication for my depression, and that fu--ed me up. I was in a straight haze. I detoxed off that medication – it was an anti-depressant, the anxiety and stuff. I'd been on it for three years and the doctor told me you gotta get off this, it's bad for you."
Angus Young created the distinctive opening guitar part for "Thuderstruck" by playing with all the strings taped up, except the B. He learned the studio trick from his older brother George Young, who was the rhythm guitarist for The Easybeats.