This is a track from I Am Not a Human Being, the eighth studio album by American rapper Lil Wayne. The song features Drake and the two Young Money MCs trade rhymes about their lesser competitors, whom they compare to gonorrhea.
Drake told MTV News about this cut: "I kind of just did my verse when I heard the beat. I knew what the song was called and what it was about eventually. Wayne's a character. [Laughs.] Expect the unexpected, I guess. It's funny and it definitely makes people [pay attention]. It's like, 'Chlamydia! Oh, I should listen to this, maybe it's educating me.' [Laughs.] It's crazy. But people like it, I got a lot of good feedback on the verse."
Mike Campbell from Tom Petty & the Heartbreakers played the slide guitar on "Sixth Avenue Heartache." There is a connection here - Wallflowers lead singer Jakob's dad, Bob Dylan, played with Tom Petty in The Traveling Wilburys.