Lofgren joined Neil Young's band at the age of 17, playing piano and guitar on the After the Gold Rush album. The musician maintained a close musical relationship with Young, appearing on his Tonight's the Night album and tour among others. He explained in an interview with Mojo magazine July 2011 why he penned this song for Keith Richards: "I'm on Neil's Tonight's the Night UK tour, I'm just 22, and in heaven. Every day, I'm meeting musicians, a dozen best friends of Keith, and he becomes a common conversation; how sick he is but what an enormous imprint he continues to make. My song was a giant thank you note saying, 'You're a medicine, we need you, why not stick around and take care of yourself.'"