The title is a play on the phrase "it's different for guys," which is something young men tell girls to explain their urges (Joe Jackson tackled the subject in his 1979 track, also called "It's Different For Girls"
). In the song, Of Montreal frontman Kevin Barnes imagines what it must be like to be a woman, starting with a didactic analysis ("aggressively objectified"), then telling it in more simple terms ("they don't spit on the streets"). A key observation comes in the refrain: "For every one psycho bitch, there's 10,000 aggro pricks."
The song was released in 2016, which was a year before the #MeToo movement picked up steam.