Hayley Williams explained the song's meaning to MTV News: "There seemed to be this thread in my brain about people who just really need to grow up and maybe open up their mind a little bit," she said. "And for me, as a girl, I've always sort of done things the way that I wanted to do them, and sometimes you get backlash for that. And I think it's really important just to love who you are. I mean, I learn it every day; anyone who says they don't have self-esteem issues is a bold-faced liar. It's really about self-empowerment and learning to leave those negative opinions behind and sort of look at those people right now and say 'Grow Up.'"
"Islands in the Stream" was originally written by The Bee Gees as an R&B song. It was originally written by the brothers for Marvin Gaye, however it was recorded instead as a duet by Kenny Rogers and Dolly Parton with the Gibb Brothers also contributing vocals.