"Give It All" is Rise Against's credo, and the song they've played live more than any other. In a Songfacts interview with lead singer Tim McIlrath
, he said: "'Give It All' is a Rise Against anthem. It is about overcoming obstacles in a way that punk rock and hardcore taught us to. It was nods to the punk rock and the DIY attitude. And then this sort of push to the listener to keep fighting to put their head down and keep on moving forward."