Shinedown open their fourth studio album with this rocker. Drummer Barry Kerch told Alternative Addiction: "It's self-explanatory; it's about that fight and just going for it. Pumping yourself up and strapping yourself in for the ride of your life."
This served as the official theme song to WWE's professional wrestling pay-per-view event Extreme Rules 2012, which took place on April 29, 2012 at the Allstate Arena in Rosemont, Illinois.
The song's music video was filmed during the 2013 Carnival Of Madness tour and was shot by Rob Fenn. The clip features both video and photo stills taken during the concerts. Shinedown frontman Brent Smith said that Fenn, "was constantly filming, taking pictures, and documenting the reinvention of the tour."
"We had such an amazing time seeing all of our fans out on the road," he added, "that we thought: what better way to present the video for our fifth single off of Amaryllis than incorporating all the footage he captured? We hope the fans love it as much as we do."
"Kickstart My Heart" is about all the ways Motley Crue gets their blood flowing without drugs. It was inspired by their bass player Nikki Sixx, who claimed he had to be revived with a shot of adrenaline to the heart after an overdose.