Before this single, The Prodigy mainly used samples for their vocal tracks. However for "Poison," their MC, Maxim, recorded the singing part. The founder of Prodigy Liam Howlett explained to Q magazine March 2008: "(Poison) was a turning point for us. Freestyling over the music. When we did that we thought, 'Why the f--k haven't we done this before."
Howlett added in the same interview: "Everyone was speeding things up, trying to do drum/n/bass. I was trying to do something that was equally as tough but really slow."
"Poison" featured in the 1999 film End Of Days.
Music For The Jilted Generation was going to be called "Music For Joyriders."
The Four Tops' "I Can't Help Myself (Sugar Pie Honey Bunch)" was written by the Motown team of Lamont Dozier, Brian Holland and Eddie Holland. The phrase "Sugar pie, honey bunch" was something Dozier's grandfather used to say when he was a kid.