McRae said regarding this song: "Anyone who's had even half a life carries a few regrets and a few ghosts with them. They come back to you when you least expect it. I wanted to put that sensation in a percussive song, something driving and repetitive, like someone trying to outrun the advancing tide."
When "Nothin' On You" reached #1 on the Hot 100, B.o.B became the first American act whose name is a palindrome to top the chart. The other two who did so prior to the Atlanta rapper were both Scandinavian groups - ABBA and A-Ha.