This song was featured in the 1999 film Fight Club; it's heard in the scene where Tyler Durden is entering a bar that's hosting Fight Club secretly in its basement.
Like many of Waits' songs, this one's written from the perspective of an interesting character: in this case, a gruff man who is endearingly, overly serious about his dream of becoming a Hollywood actor.
In Gary Numan's "Cars," the message is that cars lead to a mechanical society devoid of personal interaction. This didn't stop automakers from using it in commercials. Both Nissan and Oldsmobile have used it in ads.