This uplifting song about not giving up is the lead single and titular track from Trisha Yearwood's twelfth studio album, PrizeFighter. It marked Yearwood's first single as the lead act in six years since releasing "They Call It Falling for a Reason" in 2008.

The song features guest vocals from Kelly Clarkson. It was Yearwood's second collaboration with Clarkson, the first being the American Idol alumna's version of "Silent Night," which she recorded for her 2013 Wrapped In Red album.

The pair are friends so it was natural for Yearwood to call up Clarkson when she realized that she needed help on the cut. "When I heard this song, it was a challenge enough for me to sing," she said, "and I thought 'It needs a harmony above.'"

The empowering ballad was written by Jessi Alexander, Sarah Buxton, and Ross Copperman, "I love how 'PrizeFighter' makes me feel… like even when the odds are against me, I can do anything," Yearwood said. "It's a message we all need to hear, and the track just plain rocks!"

Yearwood said regarding the song's meaning: "'PrizeFighter' describes for me the fight we all fight, whatever it is. It's the courage to get up every day and give it your best shot, no matter the odds.

For me, I learned that strength from my mama, Gwen. She went toe to toe with breast cancer, and though she lost her battle, she fought every step of the way with grace, dignity, humor, and love. She's my prizefighter.

Whatever your battle, whoever your prizefighter is, my hope is that you draw strength from this important message."